Physiologic Action of Clostridium Welchii (type
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چکیده
Recent work reported from this laboratory (1 to 7) has shown that clostridia grow and produce toxins readily in anoxic muscle in zivo, and that they are readily introduced into dog muscles during the course of traumatizing procedures. Moreover, our previous experiments have suggested that these and perhaps other bacteria may be responsible for a toxic factor contributing to shock in traumatizing wounds. Since clostridia are known to be frequent contaminants of war wounds (8, 9) it appeared desirable to study the physiologic action of clostridial toxins in order to determine whether these toxins could produce shock 4 alone or in synergy with blood or plasma loss following trauma. Since the action of these toxins depends on the amount used, the route of injection, and the rate of injection, we have given attention to these variables. Wright (12) has criticized studies on the pharmacologic effects of Cl. welchii toxins in which large doses of toxin were administered rapidly, in a manner unlikely to have a parallel in the' clinical disease. Study of the effects of the Cl. welchii toxic filtrate has a particular interest in that the specific enzymatic nature of its probable principal component (the alpha toxin or lecithinase) (13)
منابع مشابه
The lecithinase of Clostridium bifermentans toxin.
Miles & Miles (1947, 1950) showed that culture filtrates of Clostridium bifermentarw, an organism previously shown to give the Nagler reaction (Hayward, 1943), decomposed lecithin enzymically with production of a water-soluble organic phosphoric compound. This action was inhibited not only by homologous antisera but also, though less specifically, by Clostridium welchii antitoxin. Miles & Miles...
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